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.Cell, 2007; 129: 1261 1274[52] Inoki K., Li Y., Zhu T., Wu J., Guan K.L.: TSC2 is phosphorylatedand inhibited by Akt and suppresses mTOR signalling.Nat.Cell Biol., [75] Matheny R.W.Jr., Adamo M.L.: Current perspectives on Akt Akt-2002; 4: 648 657 ivation and Akt-ions.Exp.Biol.Med., 2009; 234: 1264 1270[53] Irie H.Y., Pearline R.V., Grueneberg D., Hsia M., Ravichandran P., [76] Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.:Kothari N., Natesan S., Brugge J.S.: Distinct roles of Akt1 nad Akt2 Glycogen synthase kinase-3 regulates mitochondrial outer membra-in regulating cell migration and epithelial-mesenchymal transition.J.ne permeabilization and apoptosis by destabilization of MCL-1.Mol.Cell Biol., 2005; 171: 1023 1034 Cell, 2006; 21: 749 760[54] Jiang B.H., Liu L.Z.: PI3K/PTEN signaling in tumorigenesis and an- [77] Mayo L.D., Donner D.B.: A phosphatidylinositol 3-kinase/Akt path-giogenesis.Biochim.Biophys.Acta, 2008; 1784: 150 158 way promotes translocation of Mdm2 from the cytoplasm to the nuc-leus.Proc.Natl.Acad.Sci.USA, 2001; 98: 11598 11603[55] Jiang B.H., Liu L.Z.: Role of mTOR in anticancer drug resistance:perspectives for improved drug treatment.Drug Resist.Updat., 2008; [78] Medema R.H., Kops G.J., Bos J.L., Burgering B.M.: AFX-like Forkhead11: 63 76 transcription factors mediate cell-cycle regulation by Ras and PKBthrough p27kip1.Nature, 2000; 404: 782 787[56] Jiang P., Enomoto A., Jijiwa M., Kato T., Hasegawa T., Ishida M.,Sato T., Asai N., Murakumo Y., Takahashi M.: An actin-binding pro- [79] Momota H., Nerio E., Holland E.C.: Perifosine inhibits multiple si-tein Girdin regulates the motility of breast cancer cells.Cancer Res., gnaling pathways in glial progenitors and cooperates with temozolo-2008; 68: 1310 1318 mide to arrest cell proliferation in gliomas in vivo.Cancer Res., 2005;65: 7429 7435[57] Jiang Z.Y., Zhou Q.L., Holik J., Patel S., Leszyk J., Coleman K.,Chouinard M., Czech M.P.: Identification of WNK1 as a substrate of [80] Noguchi M., Ropars V., Roumestand C., Suizu F.: Proto-oncogeneAkt/protein kinase B and a negative regulator of insulin-stimulated TCL1: more than just a coactivator for Akt.FASEB J., 2007; 21:mitogenesis in 3T3-L1 cells.J.Biol.Chem., 2005; 280: 21622 21628 2273 2284[58] Kim A.H., Khursigara G., Sun X., Franke T.F., Chao M.V.: Akt pho- [81] Nyakern M., Cappellini A., Mantovani I., Martelli A.M.: Synergisticsphorylates and negatively regulates apoptosis signal-regulating kina- induction of apoptosis in human leukemia T cells by the Akt inhibi-se 1.Mol.Cell.Biol., 2001; 21: 893 901 tor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways.Mol.Cancer Ther., 2006; 5:[59] Kim D., Chung J.: Akt: versatile mediator of cell survival and beyond.1559 1570J.Biochem.Mol.Biol., 2002; 35: 106 115[82] Papapetropoulos A., Fulton D., Mahboubi K., Kalb R.G., O Connor[60] Kim D., Kim S., Koh H., Yoon S.O., Chung A.S., Cho K.S., ChungD.S., Li F., Altieri D.C., Sessa W.C.: Angiopoietin-1 inhibits endothe-J.: Akt/PKB promotes cancer cell invasion via increased motility andlial cell apoptosis via the Akt/survivin pathway.J.Biol.Chem., 2000;metaloproteinase production.FASEB J., 2001; 15: 1953 1962275: 9102 9105[61] Kim N.H., Kim K., Park W.S., Son H.S., Bae Y.: PKB/Akt inhibits ce-[83] Parcellier A., Tintignac L.A., Zhuravleva E., Hemmings B.A.: PKBramide-induced apoptosis in neuroblastoma cells by blocking apopto-and the mitochondria: AKTing on apoptosis.Cell.Signal., 2008; 20:sis-inducing factor (AIF) translocation.J.Cell.Biochem., 2007; 102:21 301160 1170[84] Park B.K., Zeng X., Glazer R.I.: Akt1 induces extracellular matrix[62] King F.W., Skeen J., Hay N., Shtivelman E.: Inhibition of Chk1 by ac-invasion and matrix metalloproteinase-2 activity in mouse mammarytivated PKB/Akt.Cell Cycle, 2004; 3: 634 637epithelial cells.Cancer Res., 2001; 61: 7647 7653501----- Postepy Hig Med Dosw (online), 2010; tom 64: 490-503[85] Park H.S., Kim M.S., Huh S.H., Park J., Chung J., Kang S.S., Choi [107] Tanno S [ Pobierz całość w formacie PDF ]
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.Cell, 2007; 129: 1261 1274[52] Inoki K., Li Y., Zhu T., Wu J., Guan K.L.: TSC2 is phosphorylatedand inhibited by Akt and suppresses mTOR signalling.Nat.Cell Biol., [75] Matheny R.W.Jr., Adamo M.L.: Current perspectives on Akt Akt-2002; 4: 648 657 ivation and Akt-ions.Exp.Biol.Med., 2009; 234: 1264 1270[53] Irie H.Y., Pearline R.V., Grueneberg D., Hsia M., Ravichandran P., [76] Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.:Kothari N., Natesan S., Brugge J.S.: Distinct roles of Akt1 nad Akt2 Glycogen synthase kinase-3 regulates mitochondrial outer membra-in regulating cell migration and epithelial-mesenchymal transition.J.ne permeabilization and apoptosis by destabilization of MCL-1.Mol.Cell Biol., 2005; 171: 1023 1034 Cell, 2006; 21: 749 760[54] Jiang B.H., Liu L.Z.: PI3K/PTEN signaling in tumorigenesis and an- [77] Mayo L.D., Donner D.B.: A phosphatidylinositol 3-kinase/Akt path-giogenesis.Biochim.Biophys.Acta, 2008; 1784: 150 158 way promotes translocation of Mdm2 from the cytoplasm to the nuc-leus.Proc.Natl.Acad.Sci.USA, 2001; 98: 11598 11603[55] Jiang B.H., Liu L.Z.: Role of mTOR in anticancer drug resistance:perspectives for improved drug treatment.Drug Resist.Updat., 2008; [78] Medema R.H., Kops G.J., Bos J.L., Burgering B.M.: AFX-like Forkhead11: 63 76 transcription factors mediate cell-cycle regulation by Ras and PKBthrough p27kip1.Nature, 2000; 404: 782 787[56] Jiang P., Enomoto A., Jijiwa M., Kato T., Hasegawa T., Ishida M.,Sato T., Asai N., Murakumo Y., Takahashi M.: An actin-binding pro- [79] Momota H., Nerio E., Holland E.C.: Perifosine inhibits multiple si-tein Girdin regulates the motility of breast cancer cells.Cancer Res., gnaling pathways in glial progenitors and cooperates with temozolo-2008; 68: 1310 1318 mide to arrest cell proliferation in gliomas in vivo.Cancer Res., 2005;65: 7429 7435[57] Jiang Z.Y., Zhou Q.L., Holik J., Patel S., Leszyk J., Coleman K.,Chouinard M., Czech M.P.: Identification of WNK1 as a substrate of [80] Noguchi M., Ropars V., Roumestand C., Suizu F.: Proto-oncogeneAkt/protein kinase B and a negative regulator of insulin-stimulated TCL1: more than just a coactivator for Akt.FASEB J., 2007; 21:mitogenesis in 3T3-L1 cells.J.Biol.Chem., 2005; 280: 21622 21628 2273 2284[58] Kim A.H., Khursigara G., Sun X., Franke T.F., Chao M.V.: Akt pho- [81] Nyakern M., Cappellini A., Mantovani I., Martelli A.M.: Synergisticsphorylates and negatively regulates apoptosis signal-regulating kina- induction of apoptosis in human leukemia T cells by the Akt inhibi-se 1.Mol.Cell.Biol., 2001; 21: 893 901 tor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways.Mol.Cancer Ther., 2006; 5:[59] Kim D., Chung J.: Akt: versatile mediator of cell survival and beyond.1559 1570J.Biochem.Mol.Biol., 2002; 35: 106 115[82] Papapetropoulos A., Fulton D., Mahboubi K., Kalb R.G., O Connor[60] Kim D., Kim S., Koh H., Yoon S.O., Chung A.S., Cho K.S., ChungD.S., Li F., Altieri D.C., Sessa W.C.: Angiopoietin-1 inhibits endothe-J.: Akt/PKB promotes cancer cell invasion via increased motility andlial cell apoptosis via the Akt/survivin pathway.J.Biol.Chem., 2000;metaloproteinase production.FASEB J., 2001; 15: 1953 1962275: 9102 9105[61] Kim N.H., Kim K., Park W.S., Son H.S., Bae Y.: PKB/Akt inhibits ce-[83] Parcellier A., Tintignac L.A., Zhuravleva E., Hemmings B.A.: PKBramide-induced apoptosis in neuroblastoma cells by blocking apopto-and the mitochondria: AKTing on apoptosis.Cell.Signal., 2008; 20:sis-inducing factor (AIF) translocation.J.Cell.Biochem., 2007; 102:21 301160 1170[84] Park B.K., Zeng X., Glazer R.I.: Akt1 induces extracellular matrix[62] King F.W., Skeen J., Hay N., Shtivelman E.: Inhibition of Chk1 by ac-invasion and matrix metalloproteinase-2 activity in mouse mammarytivated PKB/Akt.Cell Cycle, 2004; 3: 634 637epithelial cells.Cancer Res., 2001; 61: 7647 7653501----- Postepy Hig Med Dosw (online), 2010; tom 64: 490-503[85] Park H.S., Kim M.S., Huh S.H., Park J., Chung J., Kang S.S., Choi [107] Tanno S [ Pobierz całość w formacie PDF ]